Effect for Increasing High-Density Lipoprotein Essay Discussion Paper
Which of the following lipid lowering is most effective for increasing HDL? a. Bile Acids Binding Resins b. HMG-CoA Inhibitors c. Fibric acids d. Nicotinic acid
Fibric acids are the most successful at raising HDL (High-density lipoprotein) levels when compared to the other alternatives.
In addition to reducing triglyceride levels, fibric acids, which include gemfibrozil and fenofibrate, can also increase HDL levels by up to 20–30%.
Nicotinic acid, HMG-CoA Inhibitors, and Bile Acid Binding Resins have less profound impacts on HDL levels.
Binding of Bile Acids Resins’ main mode of action is to bind to bile acids in the stomach and prevent the absorption of cholesterol, which lowers LDL (low-density lipoprotein) levels while modestly raising HDL levels.
HMG-CoA Statins are inhibitors with their main mechanism of action being the inhibition of cholesterol production in the liver, which lowers LDL levels. Examples of statins are atorvastatin and simvastatin. These may slightly increase HDL levels as well.
Niacin, commonly known as nicotinic acid, is a kind of vitamin B3 that can also only slightly increase HDL levels. High dosages of nicotinic acid, however, might have unfavorable consequences such flushing and liver damage.
Fibric acids are the best lipid-lowering drugs for raising HDL (high-density lipoprotein) levels among the alternatives offered.
Peroxisome proliferator-activated receptors (PPARs), which control lipid metabolism and gene expression, are the main mechanism by which they function.
As a result, the synthesis of apolipoprotein A-I and lipoprotein lipase, two proteins essential to HDL metabolism, increases.
Although it can result in flushing and other adverse reactions, nicotinic acid is also efficient for raising HDL levels.
Low-density lipoprotein (LDL) cholesterol levels are predominantly reduced by bile acid binding resins and HMG-CoA inhibitors, with minimal impact on HDL levels.
The correct answer is option d. Nicotinic acid (also known as niacin) is the most effective medication for increasing HDL (high-density lipoprotein) levels. HDL is often referred to as “good cholesterol” because it helps remove excess cholesterol from the bloodstream and carry it to the liver for processing and elimination.
Bile acid-binding resins primarily lower LDL (low-density lipoprotein) levels, while HMG-CoA inhibitors (also known as statins) lower both LDL and triglyceride levels. Fibric acids primarily lower triglyceride levels but may also have a modest effect on raising HDL levels.
Nicotinic acid has been shown to significantly increase HDL levels while also reducing LDL and triglyceride levels. However, it may cause side effects such as flushing, itching, and gastrointestinal disturbances.
Therefore, it should only be used under the guidance of a healthcare professional. Effect for Increasing High-Density Lipoprotein Essay Discussion Paper