Anti-inflammatory and Antigout Drugs Essay Paper

Question

Chapter 44: Anti-inflammatory and Antigout Drugs (Group # 2)

A.R. is a 66-year-old male patient who comes to the clinic today with complaints of a painful big toe. Upon examination, the nurse notes that the toe is very red and swollen at the joint. A.R. advises the nurse not to touch his toe because it hurts so badly that he “cannot even wear a sock.” The nurse notes a significant decrease in the mobility of the big toe as well. A.R. has a history of ulcers, and the nurse notes that he consumes “several” alcoholic beverages each day. The physician sends A.R. to the laboratory for a uric acid level, and the results demonstrate a significant elevation. The physician makes a diagnosis of gouty arthritis and gives A.R. a prescription for febuxostat (Uloric) and colchicine.

1. What is the mechanism of action of colchicine, and how will this drug help A.R.?

2. What is the mechanism of action of febuxostat, and how will this drug help A.R.?

3. What side effects of febuxostat will the nurse teach the patient about?

Step 1/2

Answer :-

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1) Mechanism of action of Colchicine –

Colchicine causes the disruption and damage to the tubulin protein which will prevent the aggregation of the microtubules.

Colchicine will help the patient by reducing the inflammation and also prevent the activation of leukotriene and cytokines, thus,, help the patient in relieving pain.

Step 2/2

2). Febuxostat causes the inhibition of the enzyme xanthine oxidase. Thus, will prevent the formation of purine metabolites, thus, also decrease the levels of uric acid in the blood.

It will help the patient by decreasing uric acid levels thereby preventing the attacks of gouty arthritis. It also prevents the formation and deposition of the uric acid crystals.

Final answer

3). Side effects of febuxostat that the nurse should remind the patient are –

Arm jaw and body pain.

Diarrhoea

Breathlessness

Chest pain

Nausea, vomiting

Anti-inflammatory and Antigout Drugs Essay Paper